CBD research

Randomised Double Blind Trials

• Efficacy and Safety of Cannabidiol in Epilepsy: A Systematic Review and Meta-Analysis
• Chronic administration of cannabidiol to healthy volunteers and epileptic patients
• Effect of Cannabidiol on Drop Seizures in the Lennox-Gastaut Syndrome
• Cannabidiol in patients with seizures associated with Lennox-Gastaut syndrome (GWPCARE4): a randomised, double-blind, placebo-controlled phase 3 trial
• Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome

Open Label Trials

• Cannabidiol improves frequency and severity of seizures and reduces adverse events in an open-label add-on prospective study
• Cannabidiol in patients with Lennox-Gastaut syndrome: Interim analysis of an open-label extension study
• Pharmacokinetics and Tolerability of Multiple Doses of Pharmaceutical-Grade Synthetic Cannabidiol in Pediatric Patients with Treatment-Resistant Epilepsy
• Higher cannabidiol plasma levels are associated with better seizure response following treatment with a pharmaceutical grade cannabidiol
• Open-label use of highly purified CBD (Epidiolex®) in patients with CDKL5 deficiency disorder and Aicardi, Dup15q, and Doose syndromes
• Long-term safety and treatment effects of cannabidiol in children and adults with treatment-resistant epilepsies: Expanded access program results
• Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial

Observational Studies

• Cannabidiol for treatment of refractory childhood epilepsies: Experience from a single tertiary epilepsy center in Slovenia
• Cannabidiol for treating drug-resistant epilepsy in children: the New South Wales experience
• Long-Term Safety, Tolerability, and Efficacy of Cannabidiol in Children with Refractory Epilepsy: Results from an Expanded Access Program in the US
• Cannabidiol as a new treatment for drug-resistant epilepsy in tuberous sclerosis complex
• Potential Clinical Benefits of CBD-Rich Cannabis Extracts Over Purified CBD in Treatment-Resistant Epilepsy: Observational Data Meta-analysis

Case Studies

• The use of cannabidiol for seizure management in patients with brain tumor-related epilepsy

Randomised Double Blind Trials

• Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients
• Cannabidiol enhances consolidation of explicit fear extinction in humans

Clinical Trials

• Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report
• Effects of ipsapirone and cannabidiol on human experimental anxiety

Cross-sectional Studies (Survey)

• A Cross-Sectional Study of Cannabidiol Users
• CBD Survey Results: Cultivating Wellness

Case Studies

• Cannabidiol in Anxiety and Sleep: A Large Case Series

Randomised Double Blind Trials

• A preliminary controlled study to determine whether whole-plant cannabis extracts can improve intractable neurogenic symptoms

• Initial experiences with medicinal extracts of cannabis for chronic pain: results from 34 'N of 1' studies

Randomised Double Blind Trials

• Hypnotic and Antiepileptic Effects of Cannabidiol

Case Studies

• Cannabidiol can improve complex sleep-related behaviours associated with rapid eye movement sleep behaviour disorder in Parkinson's disease patients: a case series
• Cannabidiol in Anxiety and Sleep: A Large Case Series
• Effectiveness of Cannabidiol Oil for Pediatric Anxiety and Insomnia as Part of Posttraumatic Stress Disorder: A Case Report

Randomised Double Blind Trials

• Initial experiences with medicinal extracts of cannabis for chronic pain: Results from 34 ‘N of 1’ studies
• A preliminary controlled study to determine whether whole-plant cannabis extracts can improve intractable neurogenic symptoms
• The Effectiveness of Topical Cannabidiol Oil in Symptomatic Relief of Peripheral Neuropathy of the Lower Extremities
• Myorelaxant Effect of Transdermal Cannabidiol Application in Patients with TMD: A Randomized, Double-Blind Trial
• An experimental randomized study on the analgesic effects of pharmaceutical-grade cannabis in chronic pain patients with fibromyalgia

Observational Studies

• Chronic Pain Treatment With Cannabidiol in Kidney Transplant Patients in Uruguay

Cross-sectional Studies (Survey)

• A Cross-Sectional Study of Cannabidiol Users
• CBD Survey Results: Cultivating Wellness
  
  

   

Randomised Double Blind Trials

• Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia
• Cannabidiol (CBD) as an Adjunctive Therapy in Schizophrenia: A Multicenter Randomized Controlled Trial

Open Label Trials

• Cannabidiol for the treatment of psychosis in Parkinson's disease
• Therapeutic Effects of Prolonged Cannabidiol Treatment on Psychological Symptoms and Cognitive Function in Regular Cannabis Users: A Pragmatic Open-Label Clinical Trial

Case Studies

• Remission of severe, treatment-resistant schizophrenia following adjunctive cannabidiol

Randomised Double Blind Trials

• Efficacy and Safety of Cannabidiol and Tetrahydrocannabivarin on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Pilot Study
• Study to Evaluate the Effect of GWP42003 on Liver Fat Levels in Participants With Fatty Liver Disease

Randomised Double Blind Trials

• Controlled clinical trial of cannabidiol in Huntington's disease

Open Label Trials

• Open label evaluation of cannabidiol in dystonic movement disorders

Randomised Controlled Trails

• Low-Dose Cannabidiol Is Safe but Not Effective in the Treatment for Crohn's Disease, a Randomized Controlled Trial
• A Randomized, Double-blind, Placebo-controlled, Parallel-group, Pilot Study of Cannabidiol-rich Botanical Extract in the Symptomatic Treatment of Ulcerative Colitis

Randomised Controlled Trails

• Cannabidiol reduces cigarette consumption in tobacco smokers: Preliminary findings
• Interaction of cannabidiol and alcohol in humans
• Cannabidiol for the Reduction of Cue-Induced Craving and Anxiety in Drug-Abstinent Individuals With Heroin Use Disorder: A Double-Blind Randomized Placebo-Controlled Trial
• Cannabidiol Pharmacotherapy for Adults With Cannabis Use Disorder (CBD)
• Cannabidiol for the treatment of cannabis use disorder: a phase 2a, double-blind, placebo-controlled, randomised, adaptive Bayesian trial

Observational Studies

• Cannabidiol Attenuates the Appetitive Effects of Δ₉-Tetrahydrocannabinol in Humans Smoking Their Chosen Cannabis

Case Studies

• Cannabidiol for the treatment of cannabis withdrawal syndrome: a case report
• Cannabidiol Oil for Decreasing Addictive Use of Marijuana: A Case Report

Randomised Controlled Trails

• Palmitoylethanolamide and Cannabidiol Prevent Inflammation-induced Hyperpermeability of the Human Gut In Vitro and In Vivo-A Randomized, Placebo-controlled, Double-blind Controlled Trial

Randomised Controlled Trails

• A Study of Tolerability and Efficacy of Cannabidiol on Tremor in Parkinson's Disease

Clinical Trials

• Effects of cannabidiol in the treatment of patients with Parkinson's disease: an exploratory double-blind trial

Case Studies

• Cannabidiol in dystonic movement disorders

• Cannabidiol can improve complex sleep-related behaviours associated with rapid eye movement sleep behaviour disorder in Parkinson's disease patients: a case series

Randomised Controlled Trails

• Cannabidiol inhibits THC-elicited paranoid symptoms and hippocampal-dependent memory impairment

Open Label Trials

• Prolonged Cannabidiol Treatment Effects on Hippocampal Subfield Volumes in Current Cannabis Users
• Therapeutic Effects of Prolonged Cannabidiol Treatment on Psychological Symptoms and Cognitive Function in Regular Cannabis Users: A Pragmatic Open-Label Clinical Trial

Randomised Controlled Trials

• Oral medicinal cannabinoids to relieve symptom burden in the palliative care of patients with advanced cancer: a double-blind, placebo controlled, randomised clinical trial of efficacy and safety of cannabidiol (CBD)

Open Label Trials

• An open-label extension study to investigate the long-term safety and tolerability of THC/CBD oromucosal spray and oromucosal THC spray in patients with terminal cancer-related pain refractory to strong opioid analgesics

Observational Studies

• Report of Objective Clinical Responses of Cancer Patients to Pharmaceutical-grade Synthetic Cannabidiol

Case Studies

• Striking lung cancer response to self-administration of cannabidiol: A case report and literature review
• Dramatic response to Laetrile and cannabidiol (CBD) oil in a patient with metastatic low grade serous ovarian carcinoma
• Case Report: Clinical Outcome and Image Response of Two Patients With Secondary High-Grade Glioma Treated With Chemoradiation, PCV, and Cannabidiol

Randomised Controlled Trials

• Synthetic transdermal cannabidiol for the treatment of knee pain due to Osteoarthritis
• Efficacy and safety of cannabidiol followed by an open label add-on of tetrahydrocannabinol for the treatment of chronic pain in patients with rheumatoid arthritis or ankylosing spondylitis: protocol for a multicentre, randomised, placebo-controlled study

Open Label Trials

• Therapeutic use of cannabinoids-dose finding, effects and pilot data of effects in chronic migraine and cluster headache

Observational Studies

• A therapeutic effect of cbd-enriched ointment in inflammatory skin diseases and cutaneous scars
• Self-initiated use of topical cannabidiol oil for epidermolysis bullosa

Observational Studies

• Oral Cannabidiol Use in Children With Autism Spectrum Disorder to Treat Related Symptoms and Co-morbidities
• Brief Report: Cannabidiol-Rich Cannabis in Children with Autism Spectrum Disorder and Severe Behavioral Problems-A Retrospective Feasibility Study

Observational Studies

• Short-Term Efficacy of CBD-Enriched Hemp Oil in Girls with Dysautonomic Syndrome after Human Papillomavirus Vaccination

Cross-sectional Studies (Surveys)

• Cannabidiol (CBD) Consumption and Perceived Impact on Extrahepatic Symptoms in Patients with Autoimmune Hepatitis

Case Studies

• Cannabidiol in the Treatment of Post-Traumatic Stress Disorder: A Case Series
• Effectiveness of Cannabidiol Oil for Pediatric Anxiety and Insomnia as Part of Posttraumatic Stress Disorder: A Case Report

Case Studies

• Cannabidiol was ineffective for manic episode of bipolar affective disorder

Case Studies

• Co-medication with Cannabidiol May Slow Down the Progression of Motor Neuron Disease: A Case Report